Chronic kidney disease is a gradual loss of kidney function over time and affects 10% of the population worldwide. One of the common treatment of kidney disease is hemodialysis. Hemodialysis removes waste products and excess fluid from the bloodstream. Intradialytic hypotensive episodes still represent the most frequent complication in dialysis treatments. One major reason that causes hypotensive episodes is the application of a non-adequate net fluid removal rate. This work presents the development of a physiological closed loop system, which...